Dominican School, Manila was founded in 1958 by the Sisters of the Congregation of the Religious Missionaries of St. Domini. The school started with 79 boys and girls in the kindergarten and now caters to students of primary and secondary levels, with a population of 2,040. After many years of faithful service to the community, Dominican School can now boast of a seven-storey building with well-equipped facilities.

The turn of the twentieth century brought about dramatic changes in the life of the Philippines. In I898, Spain ceded the Philippines to the United States. Then in 1902 the Philippine Education Act established the system of public schools, and no religious instruction was allowed in those schools. There was a great need for English-speaking teachers, new Catholic schools and missionaries as most of the Spanish missionaries and clergy had left the country.